Active medicine in suppositories is typically mixed with what base?

Suppositories are designed to be inserted into the body where they can dissolve and release their active ingredients for systemic or local effect. The choice of base in suppository formulation is crucial for ensuring proper absorption and effectiveness of the medication.

An oil base is commonly used for suppositories because it provides a better consistency for molding and shapes that retain their form at room temperature. Oil-based suppositories melt at body temperature, allowing them to dissolve properly and deliver the active medicine efficiently once administered. The lipid environment created by such bases also aids in the absorption of various drug compounds, making the medication more bioavailable in the systemic circulation or local tissues.

Other bases can have limitations. For example, water bases may not maintain structural integrity, especially at room temperature, while alcohol bases can be irritating to mucosal tissues. Cream bases likewise may not provide the necessary melting characteristics and can also be moisture-sensitive, which would affect the stability and release profile of the active ingredient. Therefore, using an oil base is the most effective method for creating reliable suppositories that meet the desired therapeutic outcomes.