What is the primary use of suppositories?

Suppositories are primarily designed for rectal, urethral, or vaginal administration, allowing for systemic absorption or local effects depending on the formulation. When administered rectally, they can provide effective relief for various conditions, such as constipation, fever, or pain, as they bypass the digestive system and minimize first-pass metabolism in the liver. This method is especially useful when patients are unable to take medications orally due to nausea, vomiting, or swallowing difficulties.

In addition, suppositories used vaginally can treat local conditions, such as yeast infections or hormonal imbalances, by delivering medication directly where it is needed. Urethral suppositories may be used in certain treatments for urinary disorders.

This mode of administration is distinct from other forms, as oral administration primarily involves swallowing, inhalation delivers medication through the respiratory system, and topical application involves applying substances directly to the skin or mucous membranes. Each of these methods serves different therapeutic purposes, but suppositories are uniquely advantageous for delivering medications through the rectal, urethral, or vaginal routes.